Research

In most environments, including the human body in the context of chronic infections, bacteria spend much of their time in a starved state, limited for one or more nutrients. Bacterial starvation is important for human health because most conventional antibiotics target activities that are important for bacteria during growth like DNA synthesis and cell wall biosynthesis, but less important to non-proliferating cells. The Racki Lab aims to understand how bacteria organize and remodel their subcellular architecture to survive during starvation. Ultimately a mechanistic understanding may point the way to targeting slow-growing pathogens.